Emestrin

Description

Emestrin is a mycotoxin originally isolated from E. striata that has antimicrobial, immunomodulatory, and cytotoxic activities. It is active against the fungi C. albicans and C. neoformans, as well as the bacteria E. coli, S. aureus, and methicillin-resistant S. aureus MRSA; IC50s=3.94, 0.6, 2.21, 4.55, and 2.21 ?g/mL, respectively .2 Emestrin is a chemokine C-C motif receptor 2 CCR2 antagonist IC50=5.4 ?M in a radioligand binding assay using isolated human monocytes .3 Emestrin 0.1 ?g/mL induces apoptosis in HL-60 cells. It induces heart, thymus, and liver tissue necrosis in mice when administered at doses ranging from 18 to 30 mg/kg.