GENERAL CATALOGUE
EN450
HY-49444 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-49444
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Catalog No: HY-49444
CAS No: 793719-01-4
Category: Metabolic Enzyme Protease
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-?B. EN450 interacts with allosteric C111 in the E2 ubiquitin ligase UBE2D. EN450 induces the ternary complex formation between UBE2D and NFKB1. EN450 exerts its anti-proliferative effects through a Cullin E3 ligase and proteasome-dependent mechanism.
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