Endosidin-2

Description

Endosidin-2 ES2 is a selective inhibitor targeting the conserved exosome subunit EXO70. Endosidin-2 binds to the C-terminal domain of EXO70, inhibiting exocytosis and endosomal recycling, while promoting vacuolar trafficking in plant cells. Endosidin-2 interferes with the EXO70-mediated vesicle-to-plasma membrane anchoring process, leading to abnormal aggregation of auxin transporters such as PIN2 in the cytoplasm and redirected to vacuolar degradation, while causing abnormal Golgi structure such as cup-shaped or ring-shaped vesicles cisternae formation . Endosidin-2 can inhibit exocytosis in plant and mammalian cells and is mainly used to study the dynamic regulation of membrane trafficking such as polar growth, vesicle sorting .