Entacapone (Standard)

Description

Entacapone Standard is the analytical standard of Entacapone. This product is intended for research and analytical applications. Entacapone is a potent, reversible, peripherally acting and orally active catechol-O-methyltransferase COMT inhibitor. Entacapone inhibits COMT from rat brain, erythrocytes and liver with IC50 values of 10 nM, 20 nM, and 160 nM, respectively. Entacapone is selective for COMT over other catecholamine metabolizing enzymes, including MAO-A, MAO-B, phenolsulphotransferase M PST-M and PST-P IC50s 50 AAasAasAAmuM. Entacapone can be used for the research of Parkinsons disease. Entacapone serves as a inhibitor of FTO demethylation with an IC50 of 3.5 ?M, can be used for the research of metabolic disorders.