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Entrectinib-d4
GENERAL CATALOGUE

Entrectinib-d4

HY-12678S · 1 mg

MedChemExpress · Cat: HY-12678S

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Catalog No: HY-12678S
Category: Autophagy
Pack Size: 1 mg
Brand: MedChemExpress

Description

Entrectinib-d4 NMS-E628-d4; RXDX-101-d4 is the deuterium labeled Entrectinib HY-12678 . Entrectinib is an orally active, BBB-penetrated and centrally active inhibitor of TrkA/B/C, ROS1 and ALK, with IC50 values of 1, 3, 5, 12 and 7 nM, respectively. Entrectinib induces apoptosis and cycle arrest in cancer cells, has antitumor activity, and attenuates bleomycin-induced lung fibrosis in mice.

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