GENERAL CATALOGUE
Entrectinib
HY-12678 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-12678
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Catalog No: HY-12678
CAS No: 1108743-60-7
Category: Autophagy
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Entrectinib NMS-E628 is an orally active, BBB-penetrated and centrally active inhibitor of TrkA/B/C, ROS1 and ALK, with IC50 values of 1, 3, 5, 12 and 7 nM, respectively. Entrectinib induces apoptosis and cycle arrest in cancer cells, has antitumor activity, and attenuates bleomycin-induced lung fibrosis in mice.
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