GENERAL CATALOGUE
EP-3945
HY-173003 · 50 mg
MedChemExpress · Cat: HY-173003
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medchemexpress.com/ep-3945.html
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Catalog No: HY-173003
CAS No: 3057176-00-5
Category: GPCR G Protein
Pack Size: 50 mg
Brand: MedChemExpress
Description
EP-3945 is a potent agonist of Mas-related G protein-coupled receptor MRGPR , more effective than the MRGPRD small molecule agonist ?-Alanine HY-N0230 . MRGPR plays a crucial role in inflammatory pruritus and pain sensation. Additionally, MRGPR binds to Gq MRGPRX2, MRGPRX4, MRGPRX1 couple with Gq; MRGPRX2, MRGPRD couple with Gi , with EP-3945 measured EC50 for Gq being 211.6 nM.
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