EP300/CBP ligand 2

Description

EP300/CBP ligand 2 compound S19 is a ligand targeting the bromodomain of CREB binding protein CBP and E1A-associated protein EP300 . EP300/CBP ligand 2 can be used as a target protein ligand in the PROTAC structure, and can be coupled to the E3 ubiquitin ligase ligand through the PTOTAC Linker to synthesize PROTAC molecules with degradation effects. For example, EP300/CBP ligand 2 can be coupled with the conjugate E3 ubiquitin enzyme ligand + Linker Thalidomide-NH-C10-Boc HY-161961 to produce the PROTAC molecule dCE-2 HY-161958 .