EPHB2, His, Cynomolgus

Description

EphB2, a receptor tyrosine kinase for ephrin ligands, is overexpressed in various cancers and plays an important role in tumor progression. EPHB2 promotes endothelial-mesenchymal transition EMT and elicits associated pathologic characteristics of glioblastoma multiforme GBM such as invasion and migration. EPHB2 is epigenetically overexpressed in hypoxia, a condition highly prevalent in malignancy. Furthermore, HIF-2alpha is required for EPHB2 stabilization by hypoxia.