GENERAL CATALOGUE
Epiberberine chloride
HY-N0226A · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-N0226A
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medchemexpress.com/Epiberberine-chloride.htmlCatalog No: HY-N0226A
CAS No: 889665-86-5
Category: Immunology Inflammation
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 ?M, respectively. Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO- scavenging effect IC50, 16.83 ?M , and may protect against Alzheimer disease. Epiberberine chloride inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPK?/Akt pathways. Epiberberine has the potential effect in the research of diabetic disease.
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