GENERAL CATALOGUE
EPIC-0628
HY-162384 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-162384
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medchemexpress.com/epic-0628.html
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Catalog No: HY-162384
Category: Epigenetics
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
EPIC-0628 is an inhibitor of the HOTAIR-EZH2 interaction and promotes ATF3 expression. The long noncoding RNA HOTAIR has been found to regulate glioblastoma GBM progression and mediate DNA damage repair DDR by interacting with the catalytic subunit EZH2 of PRC2. EPIC-0628 also inhibits the ATF3-p38-E2F1 DDR pathway to inhibit the HR pathway and upregulates CDKN1A p21 expression, causing cell cycle arrest. EPIC-0628 also synergizes with Temozolomide TMZ HY-17364 to enhance its in vivo potency.
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