Epsilon-V1-2, Cys-conjugated

Description

Epsilon-V1-2, Cys-conjugated is a biological active peptide. This peptide is the ?PKC specific inhibitor. Its inhibitory activity is based on ?PKC translocation and MARCKS phosphorylation. This peptide interferes with ?PKC interaction with the anchoring protein ?RACK. This peptide contains a cysteine residue added to the C-terminus for potential S-S bond formation with a carrier protein.Pyroglutamyl pGlu peptides may spontaneously form when either Glutamine Q or Glutamic acid E is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic ?-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.