GENERAL CATALOGUE
Erastin
HY-15763 · 1 mg
MedChemExpress · Cat: HY-15763
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Catalog No: HY-15763
CAS No: 571203-78-6
Category: Apoptosis
Pack Size: 1 mg
Brand: MedChemExpress
Description
Erastin is a ferroptosis inducer. Erastin exhibits the mechanism of ferroptosis induction related to ROS and iron-dependent signaling. Erastin inhibits voltage-dependent anion channels VDAC2/VDAC3 and accelerates oxidation, leading to the accumulation of endogenous reactive oxygen species. Erastin also disrupts mitochondrial permeability transition pore mPTP with anti-tumor activity. Furthermore, Erastin can block the uptake of cystine mediated by SLC7A11 and also spares UMRC6-EV and -C91A cells from disulfidptosis under glucose starvation.
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