ERBB4 Mouse Monoclonal Antibody

Description

EnkiLife offers the ERBB4 Mouse Monoclonal Antibody. This antibody reacts with Human species and is suitable for ICC,ELISA,FC application. Alternative Names of Immunogen: HER4; ALS19; p180erbB4. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: ICC 1:50-1:200,ELISA 1:5000-1:20000,FC 1:200-1:400 Background: This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. Research Area: Apoptosis