Ethyl 3,4-dihydroxybenzoate

Description

Ethyl 3,4-dihydroxybenzoate Protocatechuic acid ethyl ester is an orally effective, blood-brain barrier-permeable, competitive prolyl hydroxylase PHD inhibitor that inhibits the hydroxylation modification of hypoxia-inducible factor HIF by PHD. Ethyl 3,4-dihydroxybenzoate stabilizes HIF-1? by inhibiting PHD, activates downstream pathways to induce autophagy and apoptosis of tumor cells, and regulates inflammatory responses, inhibits the NF-?B pathway, improves vascular permeability, and promotes osteoblast differentiation. Ethyl 3,4-dihydroxybenzoate has anti-tumor, anti-hypoxic injury, and bone metabolism regulation effects. It can also be used in the research of cardiovascular protection such as reducing myocardial ischemic damage , bone tissue engineering promoting osteogenesis/inhibiting osteoclast differentiation , and prevention and treatment of high-altitude cerebral edema.