Ethylenediaminediacetic acid

Description

Ethylenediaminediacetic acid N,N-Ethylenediglycine is an important ligand that enhances the antiproliferative activity of metal complexes. The complexes formed by ethylenediacetic acid and metal ions exhibited significant antiproliferative properties in MCF-7 cancer cell line. The metal complexes of ethylenediacetic acid were able to interact with DNA and were studied by CD and EPR spectroscopy techniques. Ethylenediaminediacetic acid and its metal complexes were able to induce cell cycle arrest at the G 0 /G 1 phase. The crystal structure analysis of ethylenediacetic acid provided important structural information for understanding its biological activity.