Etilefrine hydrochloride

Description

Etilefrine hydrochloride is a sympathetic nerve agonist and AMPK activator that selectively targets ?1/?1 adrenergic receptors. Etilefrine hydrochloride stimulates ?1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine hydrochloride also stimulates ?1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine hydrochloride also bidirectionally regulates the AMPK/Akt pathway and modulates the phosphorylation levels. Etilefrine hydrochloride can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output.