GENERAL CATALOGUE
Eurycomalactone
HY-N4327 · 1 mg
MedChemExpress · Cat: HY-N4327
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Catalog No: HY-N4327
CAS No: 23062-24-0
Category: Apoptosis
Pack Size: 1 mg
Brand: MedChemExpress
Description
Eurycomalactone is an active quassinoid could be isolated from Eurycoma longifolia Jack. Eurycomalactone is a potent NF-?B inhibitor with an IC50 value of 0.5 ?M. Eurycomalactone inhibits protein synthesis and depletes cyclin D1. Eurycomalactone enhances radiosensitivity through arrest cell cycle at G2/M phase and delayed DNA double-strand break repair. Eurycomalactone inhibits the activation of AKT/NF-?B signaling, induces apoptosis and enhances chemosensitivity to Cisplatin HY-17394 .
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