EVT801

Description

EVT801 is an orally active and selective inhibitor of VEGFR-3 IC50=11 nM , which has antitumor effects. EVT801 inhibits not only VEGF-C-induced human endothelial cell proliferation, but also tumor lymphatic angiogenesis in tumor mouse models. EVT801 can reduce tumor hypoxia, immunosuppressive cytokines CCL4, CCL5 and myeloid derived suppressor cells MDSC production. EVT801 has synergistic effect with immune checkpoint therapy ICT , which improves ICT response rate and has better inhibitory effect on cancer mouse models. EVT801 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition CuAAc with molecules containing Azide groups.