EXO1-IN-1

Description

EXO1-IN-1 Compound F684 is a potent and selective inhibitor of exonuclease 1 EXO1 IC50= 15.7 ?M . EXO1-IN-1 suppresses DNA end resection, promotes the accumulation of DNA double-strand breaks, and triggers S-phase PARylation, disrupts DNA repair pathways in homologous recombination-deficient HRD cancer cells, and selectively kills tumor cells with defects in HR genes like BRCA1/2. EXO1-IN-1 is promising for research of homologous recombination-deficient cancer such as BRCA-related tumors .