EYA1/4 Rabbit Polyclonal Antibody

Description

EnkiLife offers the EYA1/4 Rabbit Polyclonal Antibody. This antibody reacts with Human,Mouse species and is suitable for IHC,ELISA application. Alternative Names of Immunogen: Eyes absent homolog 1; Eyes absent homolog 4. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: IHC 1:50-1:100,ELISA 1:5000-1:20000 Background: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (By similarity). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Research Area: Epigenetics and Nuclear Signaling