GENERAL CATALOGUE
EZH2-IN-23
HY-174372 · 50 mg
MedChemExpress · Cat: HY-174372
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medchemexpress.com/ezh2-in-23.htmlCatalog No: HY-174372
CAS No: 3095068-20-2
Category: Epigenetics
Pack Size: 50 mg
Brand: MedChemExpress
Description
EZH2-IN-23 Compound 25 is an EZH2 inhibitor that exhibits potent enzymatic inhibition of the PRC2 complex EZH2, EED, SUZ12, AEBP2, RbAp48 with a biochemical IC50 of 0.8 nM. EZH2-IN-23 inhibits H3K27 trimethylation in cellular assays, showing an IC50 of 40 nM. EZH2-IN-23 displays good rat PKproperties with 100 % oral bioavailability.