fac-[Re(CO)3(L3)(H2O)][NO3]

Description

fac- Re CO 3 L3 H2O NO3 compound 3 , the rhenium I tricarbonyl aqua complex, is an anticancer agent associated with mitochondrial dysfunction. fac- Re CO 3 L3 H2O NO3 is cytotoxic to prostate cancer cells with IC50=0.32 ?M PC-3 cells . fac- Re CO 3 L3 H2O NO3 mainly accumulates in mitochondria, down-regulates ATP production in PC3 cells, and promotes paraptosis. However, fac- Re CO 3 L3 H2O NO3 did not induce necrosis, apoptosis and autophagy.