fac-[Re(CO)3(L6)(H2O)][NO3]

Description

fac- Re CO 3 L6 H2O NO3 compound 6 , the rhenium I tricarbonyl aqua complex, is an anticancer agent associated with mitochondrial dysfunction. fac- Re CO 3 L6 H2O NO3 is cytotoxic to prostate cancer cells, IC50=50 nM PC-3 cells . fac- Re CO 3 L6 H2O NO3 mainly accumulates in the nucleus, down-regulates ATP production in PC3 cells, and promotes apoptosis. However, fac- Re CO 3 L6 H2O NO3 did not induce necrosis, pyrodeath and autophagy.