GENERAL CATALOGUE
FC-14369
HY-171860 · 1 mg
MedChemExpress · Cat: HY-171860
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Catalog No: HY-171860
CAS No: 3066894-28-5
Category: Anti-infection
Pack Size: 1 mg
Brand: MedChemExpress
Description
FC-14369 is a PROTAC degrader targeting HIV-1 Nef protein with a DC50 value of 160 nM. FC-14369 binds to both Nef and Cereblon E3 ubiquitin ligase via its bifunctional structure, inducing Nef ubiquitination and proteasomal degradation to restore cell-surface CD4 and MHC-I expression and inhibit HIV-1 replication. FC-14369 can be used in research on HIV infection and AIDS. Pink: Nef ligand-2 HY-171862 ; Black: Ethylenediamine HY-Y0275 ; Blue: Thalidomide HY-14658
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