FD223

Description

FD223 is a potent and selective phosphoinositide 3-kinase delta PI3K? inhibitor. FD223 displays high potency IC50=1 nM and good selectivity over other isoforms IC50s of 51 nM, 29 nM and 37 nM, respectively for ?, ? and ? . FD223 exhibits efficient inhibition of the proliferation of acute myeloid leukemia AML cell lines by suppressing p-AKT Ser473 thus causing G1 phase arrest during the cell cycle. FD223 has potential for the research of leukemia such as AML.