GENERAL CATALOGUE
FdUMP triethylammonium
HY-154508 · 1 mg
MedChemExpress · Cat: HY-154508
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Catalog No: HY-154508
CAS No: 134-46-3
Category: Apoptosis
Pack Size: 1 mg
Brand: MedChemExpress
Description
FdUMP triethylammonium is the intracellular active form of 5-fluorouracil 5-FU . 5-FU is converted to FdUMP after being transported into the cell by various enzymes. FdUMP forms a ternary complex with thymidylate synthase and its cofactor 5,10-methylene tetrahydrofolate, inhibiting the activity of thymidylate synthase, which in turn leads to the suppression of DNA synthesis.
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