GENERAL CATALOGUE
FEN1-IN-1
HY-123834 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-123834
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medchemexpress.com/fen1-in-1.htmlCatalog No: HY-123834
CAS No: 824983-91-7
Category: Cell Cycle DNA Damage
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
FEN1-IN-1 compound 1 is a small molecule flap endonuclease 1 FEN1 inhibitor with antitumor activity. FEN1-IN-1 binds to the active site of FEN1 and partly achieves inhibition by the co-ordination of Mg2+ ions. FEN1-IN-1 initiaties a DNA damage response and activates the ATM checkpoint signalling pathway, the phosphorylation of histone H2AX and the ubiquitination of FANCD2 in mammalian cells. FEN1-IN-1 is promising for research of cancers.
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