Ferroptosis-IN-12

Description

Ferroptosis-IN-12 Cpd-A1 is a ferroptosis inhibitor. Ferroptosis-IN-12 exhibits effective ferroptosis inhibition in Erastin HY-15763 -treated mouse tubular epithelial cells mTECs and improves kidney function, alleviates renal tubular damage, and reduces inflammation in a dose-dependent manner in acute kidney injury AKI mouse models induced by ischemia/reperfusion I/R or cecal ligation and puncture CLP . Ferroptosis-IN-12 demonstrates good plasma stability and high distribution in kidney tissues in pharmacokinetic studies in mice. Ferroptosis-IN-12 holds promise for research in the field of acute kidney injury AKI .