Ferroptosis-IN-20

Description

Ferroptosis-IN-20 Compound 34a is a Ferroptosis inhibitor EC50: 24.2 nM targeting voltage-dependent anion channel VDAC . Ferroptosis-IN-20 inhibits VDAC oligomerization and lipid peroxidation. Ferroptosis-IN-20 reduces content of ROS, attenuates TFR1-mediated iron uptake, inhibits Fe2+ level and restores glutathione GSH level. Ferroptosis-IN-20 alleviates Folic acid HY-16637 -induced acute kidney injury AKI .