GENERAL CATALOGUE
FGFRs-IN-1
HY-170846 · 50 mg
MedChemExpress · Cat: HY-170846
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Manufacturer product page
medchemexpress.com/fgfrs-in-1.htmlCatalog No: HY-170846
Category: Metabolic Enzyme Protease
Pack Size: 50 mg
Brand: MedChemExpress
Description
FGFRs-IN-1 Compound A16 is the orally active inhibitor for FGFR, that inhibits FGFR1/2/3/4 with IC50s of 2.3, 7, 11, and 163 nM, respectively. FGFRs-IN-1 also inhibits VEGFR1/2/3, Abl, and Flt3 with IC50s of 61, 176, 112, 26, and 353 nM, respectively. FGFRs-IN-1 exhibits weak inhibitory efficacy against CYP enzymes. FGFRs-IN-1 reduces the expression of ?-SMA and collagen I, and inhibits epithelial-mesenchymal transition EMT in TGF-?1 stimulated A549 cell. FGFRs-IN-1 exhibits anti-inflammatory activity in Bleomycin HY-17565 -induced mouse pulmonary fibrosis model and CCl4 HY-Y0298 -induced mouse liver fibrosis model.
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