GENERAL CATALOGUE
Filibuvir
HY-10118 · 1 mg
MedChemExpress · Cat: HY-10118
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Catalog No: HY-10118
CAS No: 877130-28-4
Category: Anti-infection
Pack Size: 1 mg
Brand: MedChemExpress
Description
Filibuvir is an orally active, selective non-nucleoside inhibitor of the HCV nonstructural 5B protein NS5B RNA-dependent RNA polymerase RdRp . Filibuvir binds noncovalently in the thumb II allosteric pocket of NS5B. Filibuvir inhibits genotype 1a and 1b replicons with EC50s of 59 nM for both isoforms, respectively. Filibuvir preferentially inhibits elongative RNA synthesis and potently decreases viral RNA accumulation.
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