FLT1 Mouse Monoclonal Antibody

Description

EnkiLife offers the FLT1 Mouse Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat species and is suitable for ELISA,FC application. Alternative Names of Immunogen: FLT; VEGFR1. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: ELISA 1:5000-1:20000,FC 1:200-1:400 Background: Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), also known as FLT1 or VEGFR-1. It is a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia. Research Area: TGF-beta signaling pathway,PI3K-Akt signaling pathway,Hippo signaling pathway