GENERAL CATALOGUE
Fluzoparib
HY-114778 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-114778
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Manufacturer product page
medchemexpress.com/fluzoparib.htmlCatalog No: HY-114778
CAS No: 1358715-18-0
Category: Cell Cycle DNA Damage
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
Fluzoparib SHR3162 is a potent and orally active PARP1 inhibitor IC50=1.46AAasAasAA+/-0.72 nM, a cell-free enzymatic assay with superior antitumor activity. Fluzoparib selectively inhibits the proliferation of homologous recombination repair HR -deficient cells, and sensitizes both HR-deficient and HR-proficient cells to cytotoxic agents. Fluzoparib exhibits good pharmacokinetic properties in vivo and can be used for BRCA1/2-mutant relapsed ovarian cancer research.
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