Fmoc-His(3-Me)-OH

Description

Fmoc-His 3-Me OH derives Histidine-associating compounds with biological activity. Fmoc-His 3-Me OH, with Fmoc-citrulline-OH, Fmoc-His 1-Me -OH together, forms tri-peptides and shows vasodilating effect with EC50s of 2.7-4.7 mM in 1.0 mM Phenylephrine PE -contracted aorta rings. Fmoc-His 3-Me OH resin also makes Methyl-His-Gly-Lys His 3-Me -Gly-Lys , thus acts as an Ca2+ i inhibitor. Fmoc-His 3-Me OH methylates NAHIS02, making it unable to block the Alzheimers A? channel.