Fmoc-L-Asn(EDA-N3)-OH

Description

Fmoc-L-Asn EDA-N3 -OH is a click chemistry reagent containing an azide group. This building block is reported in literature for the modification of Amanitin via Click Chemistry. Alpha-Amanitin is the deadliest member of the amatoxin peptide family produced by the death-cap mushroom A. phalloides. It is an orally available, rigid, bicyclic octapeptide and one of the most lethal known natural products LD50 = 50-100 ?g/kg acting as highly selective allosteric inhibitor of the RNA polymerase II. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition CuAAc with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition SPAAC with molecules containing DBCO or BCN groups.