GENERAL CATALOGUE
FNDR-20123 free base
HY-131708 · 50 mg
MedChemExpress · Cat: HY-131708
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Manufacturer product page
medchemexpress.com/fndr-20123-free-base.htmlCatalog No: HY-131708
CAS No: 1267502-34-0
Category: Anti-infection
Pack Size: 50 mg
Brand: MedChemExpress
Description
FNDR-20123 free base is a safe, first-in-class, and orally active anti-malarial HDAC inhibitor with IC50s of 31 nM and 3 nM for Plasmodium and human HDAC, respectively. FNDR-20123 free base exerts anti-malarial activity against Plasmodium falciparum asexual stage IC50=41 nM and sexual blood stage IC50=190 nM for male gametocytes . FNDR-20123 free base inhibits HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 IC50=25, 29, 2, 11, and 282 nM, respectively and inhibits Class III HDAC isoforms at nanomolar concentrations.
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