Fosamprenavir-d4

Description

Fosamprenavir-d4 is the Deuterium-labeled Fosamprenavir HY-78726 . Fosamprenavir is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir HY-17430 . Fosamprenavir is hydrolyzed into Amprenavir VX-478 by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir can be used for the study of human immunodeficiency virus HIV-1 infection.