Fozivudine tidoxil

Description

Fozivudine tidoxil BM-211290 is an orally active thioether lipid-zidovudine ZDV conjugate with anti-HIV activity. Fozivudine tidoxil, a member of the NRTI family of agent, is incorporated into the newly synthesized strand of DNA during intracellular viral replication and irreversibly binds viral RT which disrupts viral reverse-transcription. Fozivudine tidoxil is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction CuAAc with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition SPAAC reactions with molecules containing DBCO or BCN groups.