GENERAL CATALOGUE
Fremanezumab
HY-P99019 · 1 mg
MedChemExpress · Cat: HY-P99019
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Catalog No: HY-P99019
CAS No: 1655501-53-3
Category: GPCR G Protein
Pack Size: 1 mg
Brand: MedChemExpress
Description
Fremanezumab TEV-48125 is a humanized lgG2 monoclonal antibody that selectively and potently binds to calcitonin gene related peptide CGRp IC50 values = 7.943 nM . Fremanezumab binds to mouse CGRP with an IC50 value of 19.6 nM. Fremanezumab counteracts anti-inflammatory effects of CGRP in vitro, including CGRP-mediated inhibition of LPS HY-D1056 -induced microglial activation. Fremanezumab selectively inhibits the activation of A? meningeal nociceptors by cortical spreading depression CSD in rats. Fremanezumab can be used for the study of inflammation and chronic migraine.
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