Ganglioside GM1 ammonium

Description

Ganglioside GM1 ammonium is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue. Ganglioside GM1 ammonium is one of the most abundant gangliosides in the brain which provides neuroprotection. Ganglioside GM1 ammonium exhibits anti-inflammatory property. Ganglioside GM1 ammonium has a well-balanced amphiphilic behavior. Ganglioside GM1 ammonium can reduce the fluidity of the plasma membrane that implies a retention and enrichment of the ganglioside in specific membrane domains that are called lipid rafts. Ganglioside GM1 ammonium can modify the process of differentiation, amplifies responses to neurotrophic factors, protects against excitatory amino acid-related neurotoxicity. Ganglioside GM1 ammonium can alleviate acute nerve cell damage through blocking cytotoxicity and potentiating neurotophic factors. Ganglioside GM1 ammonium can be studied in neurodegenerative diseases such as AlzheimerAAasAasAas disease.