GENERAL CATALOGUE
Garcinone D
HY-N6953 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-N6953
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Catalog No: HY-N6953
CAS No: 107390-08-9
Category: Immunology Inflammation
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Garcinone D is an activator of the STAT3/Cyclin D1 and Nrf2/HO-1 pathways, and an inhibitor of CDK2/CyclinE1 IC50 for CDK2/CyclinE1 is 28.23 ?M . Garcinone D promotes neural stem cell proliferation by activating STAT3 phosphorylation and Cyclin D1 expression and enhancing the Nrf2/HO-1 signaling pathway. In addition, Garcinone D blocks the tumor cell cycle by inhibiting CDK2/CyclinE1. Garcinone D can promote the proliferation of C17.2 neural stem cells and inhibit prostate and breast cancer.
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