GC1118

Description

GC1118 GC-1118A is a fully human anti-EGFR monoclonal antibody with binding affinity of 0.16 nM KD to EGFR. GC1118 displays potent inhibitory effects on high- and low-affinity EGFR ligand-induced signaling. GC1118 shows potent anti proliferative activity in KRAS wild-type and KRAS mutant cells. GC1118 can reach the tumor by crossing both BBB blood-brain barrier and BTB brain-tumor barrier and shows superior anti-tumor effects in various mice xenograft models. GC1118 can be used for the researches of cancer, such as colorectal cancer.