GCO-(GPO)10-GCOG

Description

GCO- GPO 10-GCOG is a GPO repeat-containing peptide with a single collagen triple helix structure similar to collagen. The cross-linked triple helix GCO- GPO 10-GCOG can form a collagen-related peptide CRP mimetic that tightly binds to the Yersinia adhesin YadA. YadA mediates the adhesion of the human enteric pathogen Yersinia enterocolitica to collagen and other extracellular matrix components, potentially interfering with host processes mediated by endogenous collagen-binding proteins in vivo. GCO- GPO 10-GCOG can be used to study YadA-associated infections.