GENERAL CATALOGUE
GDCNF-11
HY-169133 · 50 mg
MedChemExpress · Cat: HY-169133
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medchemexpress.com/gdcnf-11.htmlCatalog No: HY-169133
CAS No: 2991588-80-6
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
GDCNF-11 is a HIM-PROTAC GPX4 degrader based on the chaperone protein HSP90. GDCNF-11 promotes the ubiquitination and degradation of GPX4 through the HSP 90 chaperone complex, reduces endogenous GPX4 expression to induce ferroptosis in HT-1080 cells, and the DC50 value is 0.08 ?M Pink: Target protein ligand HY-153748 ; Blue: HSP90 ligand HY-10212 ; Black: Linker HY-W169526 .
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