Gefitinib-based PROTAC 3

Name: Gefitinib-based PROTAC 3
Brand: MedChemExpress

HY-123921 · Free Sample (0.1 - 0.2 mg)

MedChemExpress · Cat: HY-123921

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Manufacturer product page

medchemexpress.com/gefitinib-based-protac-3.html

Catalog No: HY-123921

CAS No: 2230821-27-7

Category: JAK STAT Signaling

Pack Size: Free Sample (0.1 - 0.2 mg)

Brand: MedChemExpress

Description

Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a von Hippel-Lindau ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827 exon 19 del and H3255 L858R mutantion cells, respectively.

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