GENERAL CATALOGUE
GEM144
HY-143411 · 5 mg
MedChemExpress · Cat: HY-143411
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Catalog No: HY-143411
CAS No: 2487526-28-1
Category: Apoptosis
Pack Size: 5 mg
Brand: MedChemExpress
Description
GEM144 is a potent and orally active DNA polymerase ? POLA1 and HDAC 11 dual inhibitor. GEM144 induces acetylation of p53, activation of p21, G1/S cell cycle arrest, and apoptosis. GEM144 has significant antitumor activity in human orthotopic malignant pleural mesothelioma xenografts.
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