
Z03624 · 100 ug
GenScript · Cat: Z03624
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genscript.com/enzyme/Z03624-GenCRISPR_Ultra_eSpCas9_2NLS_bas...
Description
GenCRISPR Ultra eSpCas9-2NLS-basic GMP is utilized for CRISPR gene editing applications. The Cas9 nuclease forms a stable ribonucleoprotein RNP complex with the guide RNA gRNA component. With the help of two nuclear localization signals NLS expressed with the Cas9 nuclease, the RNP complex enters the nucleus and cleaves target gene. When compared with a plasmid-based delivery system, the RNP delivery system has been observed to increase the on-target gene editing efficiency and decrease off-target effects.



