GEP44

Description

GEP44 is a peptide biased triple agonist targeting Glucagon-like peptide 1 receptor GLP-1R , neuropeptide Y1 Receptor Y1-R , and neuropeptide Y2 Receptor Y2-R . GEP44 induces Y1-R antagonist-controlled, GLP-1R-dependent stimulation of insulin secretion in both rat and human pancreatic islets by counteracting effects of Y1-R and GLP-1R agonism. GEP44 promotes insulin-independent Y1-R-mediated glucose uptake in muscle tissue and significantly reduces food intake and body weight in diet-induced obese rat models. GEP44 can be used for obesity and type 2 diabetes mellitus research.