GENERAL CATALOGUE
GGTI-286
HY-115489 · 50 mg
MedChemExpress · Cat: HY-115489
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medchemexpress.com/ggti-286.htmlCatalog No: HY-115489
CAS No: 171744-11-9
Category: GPCR G Protein
Pack Size: 50 mg
Brand: MedChemExpress
Description
GGTI-286, a potent and cell-permeable GGTase I inhibitor, is 25-fold more potent IC50=2 ?M than the corresponding methyl ester of FTI-276 HY-15873A . GGTI-286 selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells IC50s=2 and 30 ?M, respectively. GGTI-286 also potently inhibits oncogenic K-Ras4B stimulation with an IC50 of 1 ?M.
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